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Postharvest Management of Fresh Produce: Recent Advances critically
addresses the latest issues, challenges, and technological
advancements in postharvest management of fresh commodities,
especially fruits, nuts, and vegetables. The book covers the
intriguing correlation of preharvest treatments, maturity indices
and postharvest operations that significantly affect the
postharvest quality of fresh produce. Further topics include
packaging, logistics and storage technologies, the role of
microbial communities, and ‘omics’ strategies in postharvest
disease management. Special attention is given to the latest trends
of nanotechnology, internet of things (IoTs), and blockchain
technologies in food supply chain management of perishable
products. The book is a great resource for young and experienced
professionals in academia, industry, and UG/PG students to explore
a diversified range of topics in postharvest strategies relevant to
food processing, food technologies, agro-processing and quality
control.
Pulses have played a major role in human diet and are considered a
rich source of proteins. But, the major constraints in achieving
the yield of pulses are the occurrences of various diseases and
pests. Hence, there is a need to understand major fungal pathogens
and their management strategies for sustainable agriculture. The
major pulse crops in India and other Asian countries are bengal
gram, pigeon pea, black gram, green gram, lentil and peas, which
are attacked by several pathogens that cause considerable crop
damage. Bengal gram is affected mainly by wilt (Fusarium oxysporum
f. sp. ciceri), blight (Mycosphaerella pinodes) and rust (Uromyces
ciceris-arietini). The main diseases of pigeon pea are wilt
(Fusarium oxysporum) and Phytophtora stem blight (Phytophthora
drechsleri f. sp. cajani). Powdery mildew (Erysiphe polygoni) and
rust (Uromyces vicia-fabae) are the most important diseases
affecting the production of pea. This volume offers details like
symptoms, distribution, pathogens associated, predisposing factors
and epidemiology, sources of resistance and holistic management of
diseases with particular reference to those of economic importance.
Several minor diseases of lentil, green gram and of black gram are
discussed with their detailed and updated information. This volume
provides pooled information regarding the management of major
fungal phytopathogens affecting pulses.
Pulses have played a major role in human diet and are considered a
rich source of proteins. But, the major constraints in achieving
the yield of pulses are the occurrences of various diseases and
pests. Hence, there is a need to understand major fungal pathogens
and their management strategies for sustainable agriculture. The
major pulse crops in India and other Asian countries are bengal
gram, pigeon pea, black gram, green gram, lentil and peas, which
are attacked by several pathogens that cause considerable crop
damage. Bengal gram is affected mainly by wilt (Fusarium oxysporum
f. sp. ciceri), blight (Mycosphaerella pinodes) and rust (Uromyces
ciceris-arietini). The main diseases of pigeon pea are wilt
(Fusarium oxysporum) and Phytophtora stem blight (Phytophthora
drechsleri f. sp. cajani). Powdery mildew (Erysiphe polygoni) and
rust (Uromyces vicia-fabae) are the most important diseases
affecting the production of pea. This volume offers details like
symptoms, distribution, pathogens associated, predisposing factors
and epidemiology, sources of resistance and holistic management of
diseases with particular reference to those of economic importance.
Several minor diseases of lentil, green gram and of black gram are
discussed with their detailed and updated information. This volume
provides pooled information regarding the management of major
fungal phytopathogens affecting pulses.
Perinatal and Developmental Epigenetics, Volume 32, a new volume in
the Translational Epigenetics series, provides a thorough overview
of epigenetics in the early developmental and perinatal stages,
illuminating pathways for drug discovery and clinical advances.
Here, over 25 international researchers examine recent steps
forward in our understanding of epigenetic programming during
perinatal and early development. The book opens with an in-depth
introduction to known and newly discovered epigenetic marks and how
they regulate various cellular processes. Later sections examine
various prenatal and perinatal environmental experiences and their
ability to derail the normal developmental trajectory via
epigenetic reprogramming. Insights and suggestions for future
research illuminate approaches for identifying individual disease
susceptibility. Concluding chapters highlight preventative and
targeted therapeutic pathways to improve quality of life into
adulthood.
The aim of the present book is mainly to develop a series of
hemi-calix 4]naphthalene like molecular systems based on
1,1'-methylene-bis(2-naphthol) (mbn) or
1,1'-thio-bis(2-naphthol)(tbn) conjugates possessing a variety of
binding sites and study their binding and/or receptor properties
and also to synthesize their metal ion complexes. Further, then
focus of this thesis is to develop sophisticated metalloenzyme
models particularly for catecholase activity using Cu2+ complexes.
Thus all the studies reported in this book are concerned with the
hemi- calix 4]naphthalene like molecular systems.
PMThe aminobisphosphonate zoledronic acid(ZOL) has elicited
significant attention due to its remarkable anti-tumoral
activity,though its detailed mechanism of action remains unclear.
Here,we demonstrate the existence of a nuclear GSK3-NFATc2
stabilization pathway that promotes cancer growth in vitro and in
vivo and serves as a bonafide target of ZOL. Specifically, the
serine/threonine kinase GSK3 stabilizes nuclear NFATc2 through
phosphorylation of the serine-rich SP2 domain, thus protecting the
transcription factor from E3-ubiquitin ligase HDM2 mediated
proteolysis. ZOL disrupts this NFATc2 stabilization pathway through
two mechanisms, namely GSK3 inhibition and induction of HDM2
activity. Upon nuclear accumulation,HDM2 targets unphosphorylated
NFATc2 for ubiquitination at acceptor lysine residues K-684/K-897
and hence labels the factor for subsequent proteasomal degradation.
Conversely, mutagenesis induced constitutive serine phosphorylation
of the SP2 domain prevents NFATc2 from HDM2 mediated ubiquitination
and degradation by ZOL. In conclusion, this report demonstrates a
critical role of the GSK3-HDM2 signaling loop in the regulation of
NFATc2 protein stabilit
TGF has a dual role in carcinogenesis, acting as a growth inhibitor
in early tumor stages and a promoter of cell proliferation in
advanced diseases. Although this cellular phenomenon is well
established, the underlying molecular mechanisms remain elusive.
Here, we report that sequential induction of NFAT and c-Myc
transcription factors is sufficient and required for the TGF switch
from a cell cycle inhibitor to a growth promoter pathway in cancer
cells. TGF induces the expression and activation of NFAT factors,
which then translocate into the nucleus to promote c-Myc
expression. In response to TGF, activated NFAT factors bind to and
displace Smad3 repressor complexes from the c-Myc promoter. c-Myc
in turn stimulates cell cycle progression and growth through
up-regulation of D-type cyclins. Most importantly, NFAT knockdown
not only prevents c-Myc activation and cell proliferation, but also
partially restores TGF-beta-induced cell cycle arrest and growth
suppression. Taken together, this study provides the first evidence
for a Smad-independent master regulatory pathway in TGF -promoted
cell growth that is defined by sequential transcriptional
activation of NFAT and c-Myc factors.
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